High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction
Identifieur interne : 002240 ( Main/Exploration ); précédent : 002239; suivant : 002241High mental disorder rates are based on invalid measures: Questions about the claimed ubiquity of mutation-induced dysfunction
Auteurs : Jerome C. Wakefield [États-Unis]Source :
- Behavioral and Brain Sciences [ 0140-525X ] ; 2006-08.
Abstract
Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci.
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DOI: 10.1017/S0140525X06429095
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<front><div type="abstract">Three reservations about Keller & Miller's (K&M's) argument are explored: Serious validity problems afflict epidemiological criteria discriminating disorders from non-disorders, so high rates may be misleading. Normal variation need not be mild disorder, contrary to a possible interpretation of K&M's article. And, rather than mutation-selection balance, true disorders may result from unselected combinations of normal variants over many loci.</div>
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